The Lactate Receptor HCAR1: a Key Modulator of Epileptic Seizure Activity
Maxime Alessandri, Alejandro Osorio-Forero, Anita Lüthi & Jean-Yves Chatton
iSCIENCE 2024 Vol. 27, Issue 5, 109679 https://doi.org/10.1016/j.isci.2024.109679
Highlights
- The lactate receptor HCAR1 is expressed by neurons of the CNS in rodents and humans
- HCAR1 plays an important role in mitigating epileptic seizures in mice
- Lack of HCAR1 is associated with increased seizure severity, duration, and mortality
- HCAR1 activation is tightly linked to tissue glycolytic output during seizures
