Our laboratory, located at the Department of Fundamental Neurosciences, is actively looking to recruit two inquisitive, skilled, and exceptionally driven postdoctoral fellows specializing in molecular and behavioral neuroscience. Immerse yourself in the forefront of scientific exploration at our research laboratory, where we delve into the captivating realm of neurodevelopmental disorders. Our focus lies on unraveling the intricate molecular, cellular, and behavioral mechanisms that underlie brain (dys)function in the context of autism spectrum disorders (ASD) and fragile X syndrome (FXS). With a commitment to pushing boundaries, we employ a multidisciplinary approach that spans from the nanoscale to the macroscale. Our cutting-edge methodologies encompass state-of-the-art molecular biology, electrophysiology, and imaging methods, as well as a diverse array of behavioral assays. Together, we will strive to unlock new possibilities for the diagnosis, treatment, and ultimately the improvement of the lives of individuals affected by these conditions.
Project: The candidates will play a key role in understanding neurodevelopmental impairments using model systems such as Drosophila, mice, and human brain organoids. They will also develop therapeutic approaches, leveraging their expertise in molecular and behavioral neuroscience to identify targets, design interventions, and assess efficacy. The Bagni Lab focuses on ameliorating sociability and cognitive flexibility deficits observed in FXS and ASD. Extensive Drosophila and mouse resources, molecular biology (including spatial transcriptomics), imaging techniques (including calcium endomicroscopy), and advanced behavioral assays (https://wwwfbm.unil.ch/neurobau/) are available. The specific project will be discussed in detail during the interview; ideas and project conceptualization are expected.
Location: The University of Lausanne’s Department of Fundamental Neurosciences (DNF) is a leading Swiss institute known for its contributions to fundamental and translational neuroscience. Situated in the heart of Lausanne city, close to the University Hospital, the DNF provides a vibrant and inclusive scientific environment. Researchers at the DNF have access to state-of-the-art neuroscience technologies, facilitating innovation and the expansion of knowledge in the field. (https://www.unil.ch/dnf/en/home.html).
Profile and application: We are seeking applicants with a Ph.D. in Neuroscience, Cellular and Molecular Biology, or Behavioral Neuroscience, who possess a keen interest in studying neurodevelopmental disorders. Individuals with experience in fly genetics and behavior, electrophysiology, or mechanisms of gene regulation and expression are particularly encouraged to apply. Strong skills in writing, organization, and communication are essential, along with the ability to work collaboratively as a team, conceive and troubleshoot experiments, and meet project deadlines.
Expected starting date: to be agreed, preferably on November 1st, 2023
Contract length: 1 year, renewable
Funding agencies: ERANET-NEURON; Swiss National Science Foundation (SNSF).
To apply for this position (Job ID 21044), please send the following documents before August 1st, 2023:
1. A cover letter outlining your relevant work experience and research interests.
2. A comprehensive curriculum vitae (CV) detailing your academic qualifications, professional experience, and research accomplishments. Please include a list of your publications, including any conference presentations or patents, if applicable.
3. Contact information for three referees who can provide insights into your qualifications and research capabilities.
Please ensure that all documents are prepared in a clear and organized manner and submitted through the following website:
https://www.unil.ch/carrieres/en/home/menuinst/emplois.html
We look forward to reviewing your application and considering you as a potential candidate for this exciting postdoctoral opportunity.
5 Key References for the proposed projects
1. Mercaldo V, Vidimova B, Gastaldo D, Fernández E, Lo Adrian C, Cencelli G, Pedini G, De Rubeis S, Longo F, Klann E, Smit A.B., Grant S.G.N., Achsel T. and Bagni C. (2023). Altered striatal actin-dynamics drives behavioral inflexibility in a mouse of Fragile X syndrome. Neuron Mar 28;S0896-6273(23)00204-0
2. Mariano V, Kanellopoulos Alexandros K., Aiello Giuseppe, Lo Adrian C., Legius E, Achsel T and Bagni C (2023). SREBP modulates the NADP+/NADPH cycle to control night sleep in Drosophila. Nat. Commun. 14(1):763
3. Kanellopoulos A.K., Mariano V, Spinazzi M, Jae Woo Y, McLean C, Pech U, Li KW, Armstrong J.D., A, Callaerts P, Smit A.B., Abrahams B.S., Fiala A, Achsel T and Bagni C (2020). Aralar sequesters GABA into hyperactive mitochondria causing social behavior deficits. Cell, 180(6): 1178-1197.e20.
4. Woo YJ, Kanellopoulos A.K., Hemati P., Kirschen J, Nebel R.A., Wang T, Bagni C, Abrahams B.S. (2019). Domain-specific cognitive impairments in humans and flies with reduced CYFIP1 dosage. Biol. Psychiatry, S0006-3223(19)31273-9.
5. Domínguez-Iturza N, Lo A.C., Shah D, Armendáriz M, Vannelli A1, Mercaldo V, Trusel M, Li K.W., Gastaldo D., Santos AR, Callaerts-Vegh Z, D’Hooge R, Mameli M, Van der Linden A, Smit A.B, Achsel T and Bagni C (2019). The autism and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity and behaviour. Nat. Commun., 1(10): 3454.
