Roles of monocarboxylate transporters in the CNS and beyond

Monocarboxylate transporters are essential for the utilization of lactate and ketone bodies as energy substrates. A cell-specific distribution of distinct monocarboxylate transporter isoforms has been uncovered in various organs including the central nervous system. It is purported that regulation of the expression and distribution of these transporters may play critical roles for the metabolism of the different monocarboxylates under a vast array of physiological and pathophysiological conditions. Our current projects aim at deciphering the various signaling mechanisms involved in the regulation of monocarboxylate transporters expression as well as their localization in both neurons and astrocytes in relation with synaptic activity and in various altered metabolic states. For this purpose, we use numerous approaches involving cell cultures, immunocytochemistry, confocal microscopy, dynamic cell imaging, generation of transgenic animals, metabolic analyzes in vivo and in vitro, and behavioral as well as modeling studies.