It is now generally recognised that some intergenic long coding RNAs (lincRNAs) contribute to diverse aspects of mammalian biology. Individual lincRNAs have been shown to control all levels gene expression, to determine cell fate decisions and to contribute to different aspects of disease. Despite the increasing number of lincRNAs with established functions, they still account for insignificant fraction of all annotated transcripts. Which lincRNA are functional and what s the biological relevance, if any, of their extensive transcription in eukaryotes remains unknown and is one of the greatest challenges in lincRNA research.
Our research aims to increase the known functional repertoire of lincRNAs and establish their contributions to phenotypic variation and disease. To achieve this, we combine the predictive power of computational biology with extensive genetic analysis of candidates. We focus on two classes of lincRNAs, specifically those that regulate gene expression by serving as miRNA decoys (long intergenic noncoding miRNA decoying RNAs or linc-mdRNAs) and those that are transcribed from enhancers (elncRNAs).
We are a young and enthusiastic group. Enquiries from motivated and talented students and post-docs to discuss available research projects and funding possibilities are always welcome.
Prevalence and contributions of miRNA-decoying lncRNAs
Towards a functionally relevant classification of intergenic lncRNAs