Elucidation of the molecular mechanisms underlying the differential metabolic versus proliferative E2F1-mediated response of the cells to a particular stimuli.

We want to understand how E2F1 directs the cellular response either towards a metabolic or a proliferative fate in a coordinated manner. We are using different systems in which both metabolic and proliferative pathways need to be coordinated. This is the case for tissue-regeneration experiments, such as muscle-, liver- and pancreas regeneration. Partial resection of these tissues results in a proliferative burst in order to regenerate the tissue. Interestingly, metabolic pathways are at this stage, silenced. We will define particular conditions and perform ChIP-seq analysis, coupled to gene expression data. This will differentially identify a metabolic class of E2F1-target genes, with a distinct regulatory pathway.

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