Cell cycle regulators control metabolism in normal and pathological conditions such as obesity, diabetes and cancer

We focus our work on the elucidation of the mechanisms implicated in the metabolic response of the cells to particular stimuli and how this response participates in the maintenance of a transformed phenotype. The response of the cell to external stimuli depends on the cellular context and the cellular need at a particular moment,. A summary of our hypothesis and findings is depicted in the figure.
We have enough evidence to propose that cell cycle regulators, in addition to trigger proliferation of the cells they participate in the adapted switch required to the metabolic adaptation required to the particular response of the cell, such as proliferation, development, regeneration, survival, or specific function. Currently, proteins such as cyclins, cdk, or E2Fs are being studied in the context of proliferation, cell cycle regulation and cancer. However, we have already demonstrated that these factors play crucial roles in the control of metabolism. Our studies contribute to the understanding of the metabolic changes taking place during different physio-pathological conditions, such as obesity, diabetes, or cancer. Our work is based in the phenotype of mice models deficient of specific cell cycle regulators.
In particular the following projects are being developed in the lab:
1) Participation of pRB-cdk4-E2F1 in lipogenesis and glycolysis. [More]
2) Elucidation of the molecular mechanisms underlying the differential metabolic versus proliferative E2F1-mediated response of the cells. [More]
3) Oncogenic factors facilitate a metabolic switch in order to transform a normal into cancerous cell. [More]
4) Implicating other cdks in metablic control. [More]