Insulin resistance can be seen as a state in which a cell, an organ, or the whole body, do not respond to normal amounts of insulin and thus requires higher than average levels of circulating insulin to elicit its normal physiological response. It involves defects in multiple organ systems - the muscle, the liver, the pancreas and the adipose tissue- act together to produce abnormal glucose and lipid metabolism.
 
Insulin resistance is a crucial factor for the development of type 2 diabetes and a major health problem for older adults. It is the principal mechanism by which obesity is considered to increase the risk for type 2 diabetes and is a key feature of the metabolic syndrome. The elevated prevalence of obesity and type 2 diabetes in the older population has important consequences on the morbidity and mortality as well as on the economic burden on our societies.

Controversy currently exists as to whether or not aging contributes to insulin resistance. Many potential factors confound the association between aging and insulin resistance, including obesity and physical activity. In addition, body types and specific lipid depositions may distinctly influence insulin resistance.
 
Our general goals are oriented towards three main topics :

1) Insulin resistance of aging.
2) Ectopic lipid depositions and body composition.
3) Exercise efficiency and metabolic flexibility.