• Identification of transcriptomic changes leading to β-cell dysfunction

    We use global transcriptomic approaches such as microarray analysis and high throughput RNA-sequencing to identify relevant non-coding RNAs that are differentially expressed in pancreatic islets under specific physiological or pathological conditions. In particular, we explore changes occurring during pregnancy, obesity, aging and diabetes development. We then evaluate the role of the identified non-coding RNAs in insulin secretion, proliferation and apoptosis by modulating their levels in pancreatic β-cells.