Our overall translational research aims are to understand the mechanisms of neuronal death in neonatal cerebral hypoxia-ischemia, find new targets for neuroprotection and propose novel therapeutic strategies for future clinical practice.
Perinatal stroke and asphyxia are pathological conditions related to a reduction in oxygen supply (hypoxia) and/or blood perfusion (ischemia) to the brain around the time of birth. They are major causes of mortality in newborns but also morbidities with severe long-term neurological deficits in children (cerebral palsy, mental retardation, epilepsy, learning difficulties) bringing heavy social and economic burden. Our group associates a basic science researcher; Julien Puyal (PhD) and a clinical neonatologist, Anita Truttmann (MD), to unify basic and clinical strategies for neuroprotection. The long-term goal of our research is to better understand the mechanisms involved in neuronal death (and therefore brain injury) after perinatal stroke or asphyxia to find new therapeutic targets for effective translation into clinical applications to reduce brain damage and limit sequelae in children.