The cerebellum is a critical modulator of motor outputs, such as maintenance of balance and posture, coordination of voluntary movements, motor learning and cognitive functions. Our lab is interested in understanding the molecular programs that control neuron differentiation, interactions and assembly thus leading to functional circuits required as the bases for its many functions.
The cerebellar cortex is composed of a relatively small number of neuronal types, which receive only two main sources of inputs and a unique output. This simplified circuitry compared to other brain structures makes the cerebellum as a particular structure to investigate the molecular programs that lead to neurogenesis and circuit assembly.
To address these questions, our laboratory combines single-cells technologies, bioinformatic tools and in vitro/in vivo gain and loss of function strategies.