PRESENTATION

Every day and for many hours in a row, we withdraw from the external world, we loose consciousness and enter a world of dreams.

This does not mean that we have a brain disease – we just sleep, and thereby help brain recovery, memory consolidation and mental health.

How does brain activity during sleep cause these dramatic behavioral changes? How does sleep promote beneficial effects on our well-being?

We think that the generation and organization of sleep rhythms are at the core of the unique brain state of sleep. We explore and manipulate sleep rhythms in mouse through in vivo and slice recordings in combination with opto- and chemogenetics and we test their role in sleep, but also in cognition during waking. Our work has provided clues for human sleep organization and points of vulnerability for sleep disorders.

Sleep is a dynamic brain state that switches between continuity and fragility