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• Using a 3D in vitro system, the aggregating brain cell cultures developped by Prof. Paul Honegger, we induced different types of demyelination to mimic the heterogeneity in the demyelinating foci observed in multiple sclerosis pathology. The associated neuroinflammatory response is analyzed by measuring the expression of several inflammatory markers and the reactivity of microglial cells and astrocytes. The consequences on the demyelination and remyelination processes of different agents (PPARs agonists, THC) able to modulate the inflammatory response are studied in the perspective of a better understanding of therapeutic interventions. • The neuroinflammatory process triggered by environmental neurotoxicants is analyzed and discussed as a possible risk factor in the etiology of neurodegenerative diseases.
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